Wednesday, February 13, 2013

Recommendations of Aldosterone Antagonist use in Heart Failure (Eplerenone, Spironolactone)




Contraindications:
· K+:  > 5.0 meq/dl
·  Creatinine:  >2.5mg/dl in Men, or >2.0mg/dl in women


Monitoring of Eplerenone and Spironolactone

   
Drug
Monitored item
When, Frequency
Eplerenone
K+
Baseline, 1 week or 4 weeks, then periodically

Spironolactone
K+, Cr
1 week, q4 weeks x 3 months, q3 months x 1 year, then q6 months